Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropathy-functional abnormalities in the BB rat.

T Brismar

    Metabolism: Clinical and Experimental
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic rats develop neuropathy with reduced nerve conduction velocity. This is linked to decreased sodium permeability in nerve fibers, potentially explaining human diabetic neuropathy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease.

    Journal of internal medicine路2019
    Same author

    Implant density is not related to patient-reported outcome in the surgical treatment of patients with idiopathic scoliosis.

    The bone & joint journal路2018
    Same author

    The maturation of mismatch negativity networks in normal adolescence.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology路2015
    Same author

    Is training essential for interpreting cardiac computed tomography?

    Acta radiologica (Stockholm, Sweden : 1987)路2009
    Same author

    Amplitude and phase relationship between alpha and beta oscillations in the human electroencephalogram.

    Medical & biological engineering & computing路2006
    Same author

    Phase synchronization between alpha and beta oscillations in the human electroencephalogram.

    Neuroscience路2005

    Area of Science:

    • Neuroscience
    • Diabetology
    • Cellular Electrophysiology

    Background:

    • Spontaneously diabetic rats exhibit decreased motor-nerve conduction velocity, indicating neuropathy.
    • Morphological studies have not identified structural abnormalities to explain this functional deficit.

    Purpose of the Study:

    • To investigate the underlying electrophysiological mechanisms of neuropathy in spontaneously diabetic rats.
    • To identify the specific ion channel alterations responsible for reduced nerve conduction velocity.

    Main Methods:

    • Nerve excitability measurements on isolated sciatic nerve fibers.
    • Voltage-clamp analysis of the node of Ranvier membrane potential and ion permeability.
    • Assessment of sodium (Na) and potassium (K) ion channel function.

    Related Experiment Videos

    Main Results:

    • Reduced excitability of sciatic nerve fibers from diabetic rats.
    • Decreased Na-equilibrium potential, suggesting axoplasmic Na accumulation.
    • Reduced specific Na permeability due to increased inactivation and decreased basal permeability.
    • Increased delayed K permeability in some nodes, indicative of early demyelination.
    • Decreased Na permeability identified as the primary factor for reduced conduction velocity.

    Conclusions:

    • Reduced Na permeability at the node of Ranvier is the main cause of decreased nerve conduction velocity in diabetic rats.
    • These findings suggest a similar mechanism may underlie reversible dysfunction in human diabetic neuropathy.