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Lymphocyte abnormalities in the BB rat.

R Jackson, P Kadison, J Buse

    Metabolism: Clinical and Experimental
    |July 1, 1983
    PubMed
    Summary
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    The BB rat exhibits T cell lymphocytopenia, lacking W3/25+ T cells in peripheral blood and spleen, impacting Concanavalin A responsiveness. These distinct immune cell abnormalities differ from human type I diabetes.

    Area of Science:

    • Immunology
    • Endocrinology
    • Animal Models

    Background:

    • The BB rat is a model for type 1 diabetes.
    • It exhibits T cell lymphocytopenia, specifically a deficit in W3/25+ T cells.

    Purpose of the Study:

    • To investigate the distribution and function of W3/25+ T cells in BB rats.
    • To compare lymphocyte abnormalities in BB rats to human type I diabetes.

    Main Methods:

    • Analysis of lymphocytes from spleen and thymus using monoclonal antibody W3/25.
    • Assessment of Concanavalin A (Con A) responsiveness in peripheral blood, spleen, and thymus.

    Main Results:

    • W3/25+ T cells were absent in the spleen but present in the thymus of BB rats.
    • Con A responsiveness correlated with W3/25+ T cell presence across lymphoid compartments.

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  • BB rat lymphocyte abnormalities differ from those in human type I diabetes.

    • Conclusions:

    • The study identifies a specific T cell deficiency in BB rats.
    • Con A responsiveness is directly linked to W3/25+ T cell presence in this model.
    • BB rat immune dysregulation presents a distinct profile compared to human type I diabetes.