Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The origin of human triploids.

P A Jacobs, R R Angell, I M Buchanan

    Annals of Human Genetics
    |July 1, 1978
    PubMed
    Summary

    This study investigated the origins of triploidy in spontaneous abortuses. Most triploid fetuses resulted from dispermy, with a smaller percentage arising from abnormal parental meiosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patricia A. Jacobs (1934-2026).

    American journal of human genetics·2026
    Same author

    Improving medical students' communication competencies to deal with intimate partner violence using clinical simulations in Mozambique.

    BMC medical education·2021
    Same author

    Patterns of cardiovascular risk and disease in HIV-positive adults on anti-retroviral therapy in Mozambique.

    Cardiovascular journal of Africa·2020
    Same author

    Male breast cancer, age and sex chromosome aneuploidy.

    British journal of cancer·2013
    Same author

    Self-mixing flow sensor using a monolithic VCSEL array with parallel readout.

    Optics express·2010
    Same author

    Renewable resources as a key to green chemistry.

    Communications in agricultural and applied biological sciences·2010

    Area of Science:

    • Genetics
    • Reproductive Biology
    • Developmental Biology

    Background:

    • Triploidy, a condition where a fetus has three sets of chromosomes, is a common cause of spontaneous abortion.
    • Understanding the origins of triploidy is crucial for reproductive medicine and genetic counseling.

    Purpose of the Study:

    • To determine the parental origin of the extra haploid set in triploid fetuses.
    • To elucidate the meiotic errors leading to triploidy, specifically dispermy and abnormal gamete formation.

    Main Methods:

    • Analysis of 26 triploid fetuses from spontaneous abortuses.
    • Utilized fetal and parental heteromorphisms to trace the origin of the additional haploid set.
    • Applied a maximum-likelihood method to model the data and estimate the frequency of different etiological events.

    Main Results:

    • In 21 analyzed cases, 17 had a paternal origin and 3 had a maternal origin for the extra chromosome set.
    • The data best fit a model where 66.4% of triploids resulted from dispermy (fertilization by two sperm).
    • 23.6% were attributed to fertilization by a diploid sperm (due to male meiotic error) and 10% to a diploid egg (due to female meiotic error).

    Conclusions:

    • Paternal dispermy is the predominant cause of triploidy in spontaneous abortions.
    • Errors in male meiosis (diploid sperm formation) are a more frequent contributor than errors in female meiosis (diploid egg formation).
    • These findings refine our understanding of the mechanisms leading to chromosomal abnormalities in early human development.

    Related Experiment Videos