Related Experiment Video
Updated: Sep 24, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
[Mechanism of the diuretic action of parathormone]
Abstract:
The effect of parathyroidin, calcium chloride and parathyroidin combined with verapamil (blocking the inclusion of calcium ions into cells) on diuresis and electrolyte excretion with the urine was studied in experiments on dogs. It was shown that after a single intravenous injection of parathyroidin in a dose of 2 U/kg body weight diuresis and natriuresis twice augmented and potassium excretion increased 1.6 times one hour following the drug injection. The intravenous injection of 10% calcium chloride solution or parathyroidin combined with verapamil did not produce such an effect. The mechanism of parathyroid hormone diuretic action is likely to be due to intensified calcium ion inclusion into the renal tubular cells.
Related Concept Videos
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Antihypertensive Drugs: Action of Diuretics
Antihypertensive Drugs: Thiazide-Class Diuretics
Antihypertensive Drugs: Potassium-Sparing Diuretics
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion
Physiology of the Genitourinary System III: Urine Concentration and Dilution

