Formulation and bioavailability of directly compressed oxytetracycline hydrochloride tablets

Different tablet formulations containing various vehicles were selected for this study. These tablets were prepared using different proportions of either single or binary vehicles, and were found to possess different disintegration times. A significant correlation was obtained between the dissolution time (T50) and the urinary excretion data as well as their disintegration time. The dissolution rate of the produced tablets therefore can affect their physiological availability which in turn was dependent upon the type of vehicle used and its actual concentration in the formula. Other factors such as the type and concentration of the lubricant(s), hardness values of the tablets prepared, solubility of the drug as well as interactions between the drug and vehicles used may also play a part.