[Pathogenetic variance and diagnostic criteria in neurotoxoplasmosis]

With reference to the special position of neurotoxoplasmosis in regard of the detection of postnatal infection with Toxoplasma gondii the authors present 18 cases of this illness. The main factor responsible for the diagnostic uncertainty proves to be the blood-brain-liquor barrier which is responsible both for the behaviour of the parasite in the CNS and for immunological reactivity. Attention is drawn to the advisability of considering all anamnestic, clinical and paraclinical data and of long-term observation of the patient. Cases treated by the authors are discussed in greater detail as examples of basis pathogenetical variants.