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Effect of a protein-bound polysaccharide PS-K on the complement system.
Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
|January 1, 1983
Summary
Coriolus versicolor PS-K, an immunomodulator, enhances the immune system by boosting serum complement levels. This protein-bound polysaccharide shows potential in modulating host immune responses.
Area of Science:
- Immunology
- Biochemistry
- Pharmacology
Background:
- Coriolus versicolor PS-K is a protein-bound polysaccharide used as an immunomodulator.
- It is known to restore cellular immune response and exhibit antitumor activity.
Purpose of the Study:
- To investigate the effect of PS-K on serum complement levels in guinea pigs and humans.
- To explore the impact of PS-K on specific complement components and pathways.
Main Methods:
- Hemolytic assays were used to assess classical and alternative complement pathway activity.
- Complement component levels (C1q, C4, C3, C5, C9, properdin, C3 activator, C1-inhibitor) were measured.
- Crossed immunoelectrophoresis was employed to analyze plasma protein conversion.
Main Results:
- PS-K increased serum complement levels in both guinea pigs and humans.
- In guinea pigs, C3 levels increased, and C3 biosynthesis was accelerated.
- In humans, C5 and C9 levels decreased, and a conversion of beta 1C to beta 1A was observed.
Conclusions:
- PS-K may potentiate host immune response by increasing serum complement levels.
- Evidence suggests PS-K activates the complement system, contributing to its immunomodulatory effects.