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Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy.

K B Dahl, A Nyfors, H Brodthagen

    Archives of Dermatological Research
    |June 29, 1978
    PubMed
    Summary
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    PUVA therapy for psoriasis significantly reduces neutrophils, a key immune cell, within the first week. This decrease correlates with psoriasis symptom improvement, suggesting neutrophils play a role in the condition.

    Area of Science:

    • Dermatology
    • Immunology
    • Phototherapy

    Background:

    • Chronic recalcitrant psoriasis is an inflammatory skin condition requiring effective treatment.
    • Psoriatic lesions are characterized by immune cell infiltration, including neutrophils.
    • Phototherapy, such as PUVA (psoralen plus ultraviolet A), is a common treatment for psoriasis.

    Purpose of the Study:

    • To investigate the effect of PUVA therapy on leukocyte and differential counts in patients with psoriasis.
    • To determine if changes in neutrophil counts correlate with clinical improvement of psoriasis during PUVA treatment.

    Main Methods:

    • Leukocyte and differential blood counts were performed on 56 patients before and weekly during PUVA treatment.
    • Statistical analysis was used to assess the significance of changes in cell counts and their correlation with clinical outcomes.

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    Main Results:

    • A statistically significant decrease (P < 0.01) in the percentage of neutrophils was observed during the first week of PUVA therapy.
    • This reduction in neutrophils was significantly correlated with the clinical clearing of psoriasis (P = 0.02).
    • The findings suggest a reduction in immunocompetent neutrophils within psoriatic lesions during PUVA treatment.

    Conclusions:

    • PUVA therapy leads to a rapid and significant decrease in neutrophil counts in patients with psoriasis.
    • The reduction in neutrophils is closely linked to the therapeutic efficacy of PUVA in improving psoriasis symptoms.
    • These results indicate that neutrophils may be a key factor in the pathogenesis of psoriasis, targeted by PUVA therapy.