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Phenazopyridine-induced hemolytic anemia.

H M Noonan, M Kimbrell, W B Johnson

    Urology
    |June 1, 1983
    PubMed
    Summary
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    Phenazopyridine hydrochloride, a urinary analgesic, can cause hemolytic anemia in elderly patients. This drug should be used cautiously in older adults and those with kidney problems.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Geriatrics

    Background:

    • Phenazopyridine hydrochloride is a common urinary tract analgesic.
    • Elderly patients and individuals with renal insufficiency represent vulnerable populations for adverse drug reactions.

    Observation:

    • An elderly male patient presented with acute hemolytic anemia.
    • The patient had recently been treated with phenazopyridine hydrochloride for a urinary tract issue.

    Findings:

    • The presented case demonstrates a direct toxic reaction to phenazopyridine hydrochloride, leading to hemolytic anemia.
    • The underlying mechanisms of this drug-induced toxicity are explored, highlighting potential pathways for red blood cell destruction.

    Implications:

    Related Experiment Videos

  • This case underscores the importance of careful drug selection and monitoring in elderly patients.
  • Healthcare providers should exercise caution when prescribing phenazopyridine hydrochloride to patients with impaired renal function.
  • Awareness of phenazopyridine-induced hemolytic anemia is crucial for timely diagnosis and management in at-risk populations.