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[Bone findings in psoriasis].

H Holzmann, N Hoede, K Hahn

    Archives of Dermatological Research
    |July 28, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Psoriasis patients can exhibit early skeletal changes, including abnormal bone scans of the skull. This study found pathological nuclide uptake in the skulls of three female psoriatic patients, suggesting early bone involvement.

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    Area of Science:

    • Dermatology
    • Nuclear Medicine
    • Skeletal Biology

    Background:

    • Psoriasis is a chronic inflammatory disease.
    • Skeletal involvement in psoriasis is increasingly recognized.
    • Early detection of bone changes is crucial for management.

    Purpose of the Study:

    • To investigate early skeletal changes in psoriatic patients using scintigraphy.
    • To identify potential bone abnormalities in psoriatic patients beyond joint involvement.

    Main Methods:

    • Scintigraphy using Technetium-99m diphosphonate (Tc-diphosphonate) was performed.
    • Forty psoriatic patients were examined.
    • Skull and joint scans were analyzed for pathological nuclide uptake.

    Main Results:

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    • Abnormal, diffuse, and circumscribed pathological nuclide uptake was observed in the skulls of three female psoriatic patients.
    • These findings suggest early abarticular (non-joint) proliferation and affection of the skeleton.
    • The skull scan findings were comparable to positive joint scans in psoriatic arthritis.

    Conclusions:

    • Scintigraphy can detect early, subclinical skeletal involvement in psoriasis patients.
    • Skull bone scans may serve as an indicator of early psoriatic skeletal disease.
    • Further research is warranted to understand the implications of these early bone changes.