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Iopromide. Clinical experience with a new non-ionic contrast medium.
Acta Radiologica: Diagnosis
|January 1, 1983
Summary
This study introduces a new non-ionic contrast medium for urography. It demonstrated good visualization of the kidneys with no adverse laboratory effects, suggesting suitability for imaging.
Area of Science:
- Radiology
- Pharmacology
Background:
- A novel non-ionic, renally excreted contrast medium was developed.
- The contrast medium is stable in aqueous solution, allowing direct application.
Purpose of the Study:
- To evaluate the clinical safety and efficacy of a new contrast medium for urography.
- To assess the pharmacokinetic profile and laboratory parameter changes following administration.
Main Methods:
- Urography was performed in 7 patients using 30-100 ml of the contrast medium (300 mg I/ml).
- Laboratory blood and urine parameters were monitored for 6 days post-injection.
- Pharmacokinetics were determined, and reproducibility was assessed in 6 healthy volunteers.
Main Results:
- Good demonstration of kidneys and pelvicalyceal details, with partial visualization of the urinary bladder due to reduced diuresis.
- No significant laboratory parameter changes attributable to the contrast medium were observed.
- Pharmacokinetics were characterized by high polarity, negligible heterotopic elimination, and renal elimination via glomerular filtration; no metabolization occurred.
Conclusions:
- The new contrast medium is well-tolerated and suitable for urography and angiography.
- It provides adequate visualization of renal structures with a favorable safety profile.