Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunity to Salmonella infection.

T K Eisenstein, B M Sultzer

    Advances in Experimental Medicine and Biology
    |January 1, 1983
    PubMed
    Summary

    This review clarifies Salmonella infection complexities, suggesting killed vaccines are effective against typhoid fever, challenging the notion that only live vaccines or cellular immunity suffice. This has implications for improving current typhoid vaccines and understanding Salmonella immunity mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule.

    Microbes and infection·2002
    Same author

    The effects of drugs and neuropeptides on immunomodulation and opportunistic infection: summary of symposium 2.

    Advances in experimental medicine and biology·2001
    Same author

    Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.

    International immunopharmacology·2001
    Same author

    Morphine inhibits mucosal antibody responses and TGF-beta mRNA in gut-associated lymphoid tissue following oral cholera toxin in mice.

    Journal of immunology (Baltimore, Md. : 1950)·2001
    Same author

    The involvement of Ran GTPase in lipopolysaccharide endotoxin-induced responses.

    Journal of endotoxin research·2001
    Same author

    A single point mutation at the 3'-untranslated region of Ran mRNA leads to profound changes in lipopolysaccharide endotoxin-mediated responses.

    The Journal of biological chemistry·2001

    Area of Science:

    • Immunology
    • Microbiology
    • Vaccinology

    Background:

    • Salmonella infections, particularly typhoid fever, present complex immunological challenges.
    • Current understanding of immunity to Salmonella is debated, influencing vaccine development.
    • Existing typhoid vaccines, like acetone-killed cell preparations, exhibit significant toxicity.

    Purpose of the Study:

    • To clarify complex issues surrounding Salmonella infection and immunity.
    • To evaluate the efficacy of different vaccine types against Salmonella.
    • To inform improvements in current typhoid vaccine strategies.

    Main Methods:

    • Comprehensive literature review and data presentation.
    • Analysis of existing research on Salmonella immunity.
    • Comparative assessment of cellular vs. humoral immunity in Salmonella infection models.

    Main Results:

    • Evidence suggests killed Salmonella vaccines are highly effective in various mouse strains and humans.
    • The belief that only cellular immunity protects against Salmonella appears unfounded.
    • Acetone-killed cell typhoid vaccines demonstrate considerable toxicity, necessitating vaccine improvement.

    Conclusions:

    • Killed Salmonella vaccines are effective, challenging the necessity of live vaccines for S. typhi.
    • Rethinking the mechanisms of immunity to Salmonella is crucial.
    • There is a need to develop less toxic and more effective typhoid vaccines.

    Related Experiment Videos