Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal blood flow autoregulation in developing swine.

N M Buckley, P Brazeau, I D Frasier

    The American Journal of Physiology
    |July 1, 1983
    PubMed
    Summary

    Renal blood flow autoregulation is minimal in newborn swine and develops over the first postnatal month. This study tracked pressure-flow relationships to understand this crucial kidney function development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The use of pigs as an animal model to evaluate the efficacy, potency and specificity of two growth hormone releasing factor analogues.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2001
    Same author

    Effect of aging on growth hormone-induced insulin-like growth factor-I secretion from cultured rat chondrocytes.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2000
    Same author

    Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2000
    Same author

    Healing of experimental aneurysms. II: Platelet extracts can increase the thickness of the neointima at the neck of treated aneurysms.

    Journal of neuroradiology = Journal de neuroradiologie·1999
    Same author

    Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.

    Proceedings of the National Academy of Sciences of the United States of America·1998
    Same author

    Nitrogen balance and mineral excretion in growing male pigs injected with a human growth hormone-releasing factor analog.

    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·1998

    Area of Science:

    • Physiology
    • Nephrology
    • Developmental Biology

    Background:

    • Renal blood flow autoregulation is vital for maintaining kidney function.
    • Understanding its development in mammals is crucial for neonatal care and research.

    Purpose of the Study:

    • To investigate the development of renal autoregulation in swine from birth to 2 months.
    • To characterize pressure-flow relationships in the developing renal circulation.

    Main Methods:

    • Studied 62 swine (1 day-2 mo old) using anesthesia and hemodynamic monitoring.
    • Measured aortic and vena caval pressures, renal and femoral arterial flows.
    • Assessed renal vascular resistance (RVR) changes via aortic occlusion and in situ renal perfusion.

    Main Results:

    • Renal vascular resistance (RVR) showed rapid adjustments (within 5s) and stabilization (within 2 min).
    • An autoregulatory range in pressure-flow relationships was observed in animals from 2 weeks of age.
    • Autoregulation was negligible at birth, indicating a developmental process.

    Conclusions:

    • Renal blood flow autoregulation is not present at birth in this mammal.
    • This autoregulatory capacity develops progressively during the first postnatal month.
    • Findings highlight critical developmental changes in renal hemodynamics during early life.

    Related Experiment Videos