Related Experiment Video

Updated: Oct 2, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
08:10

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

[Clinical practice of systemic hyperthermia therapy and immune reactions of the host]

S Koga, M Maeta, A Izumi

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |April 1, 1983
    PubMed

    The effect of extracorporeally induced total-body hyperthermia (TBHT) on host immunocompetence was described. 1) Partial response (more than 50% of tumor regression) was observed in 4 of 13 evaluable patients and pain relief was obtained in 3 of 6 patients who had been suffered from pain before receiving TBHT. 2) In vitro hyperthermia (39 degrees, 42 degrees C) depressed the cytotoxic activity of murine lymphocytes against MH-134 cells as well as PHA-induced blastogenesis. In vitro hyperthermia (42 degrees C) also resulted in a marked decrease in the capability of E-rosetting and PHA-induced blastogenesis of human lymphocytes. However, human lymphocytes blastogenesis was enhanced after in vitro heating at 39 degrees C. 3) E-rosetting capability and PHA-induced blastogenesis of lymphocytes were depressed just immediately after the treatment in patients treated with TBHT, which returned to pretreatment levels within a week. 4) Decreased PHA and PPD skin reactions remained up to 3 weeks after the last TBHT. 5) Serum levels of immunoglobulin, complement and alpha 2-macroglobulin were slightly affected by TBHT, and serum haptoglobin showed a tendency to decrease.

    More Related Videos

    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management06:43

    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

    Published on: November 21, 2017

    In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System06:45

    In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

    Published on: July 2, 2020

    Related Concept Videos

    Factors Affecting Body Temperature01:28

    Factors Affecting Body Temperature

    As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
    Factors may  include:
    Increased Body Temperature01:25

    Increased Body Temperature

    A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
    Methods of reducing fever01:22

    Methods of reducing fever

    The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
    Pharmacological Methods of Reducing Fever:
    Decreased Body Temperature01:29

    Decreased Body Temperature

    A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
    Homeostatic Imbalances in Body Temperature01:19

    Homeostatic Imbalances in Body Temperature

    Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
    Acute Inflammation III: Local and Systemic Effects01:25

    Acute Inflammation III: Local and Systemic Effects

    Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...