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[Development of antitumor agents: retrospection and perspective]
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 1, 1983
Summary
This study reviews 30 years of antitumor screening using rodent models and introduces a new NCI system, including a mouse ovary tumor model. Understanding drug mechanisms and resistance is key to developing new antitumor compounds.
Area of Science:
- Oncology
- Pharmacology
- Drug Discovery
Context:
- Discusses 30 years of experience with rodent tumor models for antitumor screening.
- Introduces a new antitumor screening system at the National Cancer Institute (NCI), U.S.A.
- Highlights a recently adopted mouse ovary tumor model for drug evaluation.
Purpose:
- To review established methods and introduce novel approaches in antitumor drug screening.
- To emphasize the importance of detailed studies on the mechanism of action and toxicity of existing antitumor drugs.
- To explore new strategies for identifying novel antitumor compounds.
Summary:
- Reviews past 30 years of antitumor screening using rodent models.
- Introduces the NCI's new screening system and mouse ovary tumor model.
- Suggests studying existing drug mechanisms and toxicity to inspire new compound discovery.
- Presents Ling's approach to drug resistance, linking acquired resistance to natural cellular mutations.
Impact:
- Provides insights into the evolution of antitumor screening methodologies.
- Facilitates the development of new antitumor agents by understanding drug action and resistance.
- Contributes to advancing cancer research and therapeutic strategies.