Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium toxicity in a neonate.

P Morrell, G R Sutherland, P K Buamah

    Archives of Disease in Childhood
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of age in rodent models of focal and forebrain ischemia.

    Stroke·1996
    Same author

    bcl-w, a novel member of the bcl-2 family, promotes cell survival.

    Oncogene·1996
    Same author

    Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization.

    Genomics·1996
    Same author

    The effects of calcium on the thermal stability and activity of manganese peroxidase.

    Archives of biochemistry and biophysics·1996
    Same author

    Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-kinase gene.

    Genomics·1996
    Same author

    Asymptomatic large pituitary adenomas discovered at autopsy.

    Surgical neurology·1996
    Same journal

    Protecting adolescent confidentiality in the digital age: a global call for adolescent-informed electronic health records.

    Archives of disease in childhood·2026
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    See all related articles

    Severe transplacental lithium toxicity can affect neonates, causing functional damage to the cardiovascular, renal, and neuromuscular systems. While some functions normalize by age one, developmental delay may persist.

    Area of Science:

    • Neonatal Medicine
    • Toxicology
    • Pharmacology

    Background:

    • Lithium is a mood stabilizer used during pregnancy.
    • Transplacental transfer of lithium can occur, posing risks to the fetus.
    • Monitoring lithium levels is crucial for maternal and fetal well-being.

    Observation:

    • A neonate presented with severe symptoms of lithium toxicity following maternal lithium exposure.
    • Clinical examination revealed significant functional impairment across cardiovascular, renal, and neuromuscular systems.
    • No structural abnormalities were identified on initial assessment.

    Findings:

    • The neonate exhibited gross functional lesions in multiple organ systems.
    • Cardiovascular and renal functions showed normalization by one year of age.

    Related Experiment Videos

  • Persistent developmental delay was observed at the one-year follow-up.

    • Implications:

    • This case highlights the potential for severe functional, yet reversible, organ damage from transplacental lithium toxicity.
    • It underscores the importance of careful lithium management during pregnancy and long-term neurodevelopmental monitoring of exposed infants.
    • Further research into the mechanisms of lithium-induced neurodevelopmental effects is warranted.