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Related Experiment Videos

Tissue adhesive therapy for corneal perforations.

L W Hirst, W E Smiddy, E De Juan

    Australian Journal of Ophthalmology
    |May 1, 1983
    PubMed
    Summary

    Tissue adhesive offers a promising treatment for corneal perforations, significantly reducing enucleation rates. This study highlights its effectiveness in managing various causes of corneal injury.

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    Area of Science:

    • Ophthalmology
    • Corneal Surgery
    • Wound Healing

    Background:

    • Corneal perforations and descemetoceles pose significant risks to vision.
    • Traditional treatments for corneal perforations have varying success rates.
    • The introduction of tissue adhesive aimed to improve outcomes for these critical conditions.

    Purpose of the Study:

    • To evaluate the impact of tissue adhesive introduction on the management of non-traumatic corneal perforations.
    • To assess the efficacy of tissue adhesive in reducing enucleation rates.
    • To analyze the causes of corneal perforations treated at The Wilmer Institute.

    Main Methods:

    • Retrospective review of 104 consecutive non-traumatic corneal perforation or descemetocele cases from 1960-1980.
    • Follow-up data obtained from medical records or referral physicians for 87 cases.
    • Comparison of enucleation rates before and after the introduction of tissue adhesive in 1974.

    Main Results:

    • Bacterial corneal ulcers were the most common cause (49%), followed by exposure (13%) and chemical burns (12%).
    • The enucleation rate decreased from 19% in the pre-tissue adhesive era to 6% in the tissue adhesive treated group.
    • Tissue adhesive demonstrated a trend towards improved outcomes in managing corneal perforations.

    Conclusions:

    • Tissue adhesive represents an effective therapeutic option for non-traumatic corneal perforations.
    • The use of tissue adhesive is associated with a reduced need for enucleation.
    • Expanded utilization of tissue adhesive may further enhance the management of complex corneal conditions.

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