[Effect of kappa-casein glycomacropeptide on gastrointestinal motility in dogs]

Glycomacropeptide, which provoked a significant inhibition of food motility of the stomach fundus on intravenous injection to dogs in a dose of 10 mg, was isolated from the products of restricted pepsin proteolysis of cow kappa-casein with the aid of gel chromatography on Sephadex G-25 and G-10. Glycomacropeptide administered on an empty stomach produced cyclic-repetitive vomiting. Physiological action of glycomacropeptide (inhibition of gastric secretion and motility) may play an important role in the preservation of biologically active milk proteins and peptides in the gastrointestinal tract of the newborn.