[Effect of choline compounds on rosette formation in mouse lymphocytes]

The effects of some choline compounds (acetylcholine, benzoylcholine, phosphorylcholine) on immune rosette-formation were studied in experiments on 150 BALB/c mice immunized with sheep red blood cells. Low concentration of the choline-containing substances (from 10(-14) to 10(-12) M) stimulated immune rosette-formation, whereas high concentrations (from 10(-8) to 10(-5) M) inhibited it. The blockade of lymphocyte cholinoreceptors with atropine reversed the action of phosphorylcholine on the processes of rosette-formation. Interaction of immune and mediator receptors is discussed.