Related Experiment Video

Updated: Aug 16, 2026

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

[Pneumococcal serotyping in France. Development (1978-1982) and vaccine covering]

P Geslin, G Sissia, A Frémaux

    Bulletin Europeen De Physiopathologie Respiratoire
    |March 1, 1983
    PubMed

    Insights

    This study analyzed 2,449 pneumococcus strains in France, identifying the most common serotypes. A 23-valent vaccine demonstrated broader coverage against invasive pneumococcal disease strains.

    Area of Science:

    • Microbiology and Immunology
    • Epidemiology
    • Vaccinology

    Context:

    • Pneumococcal infections pose a significant public health challenge.
    • Serotyping is crucial for understanding pathogen epidemiology and vaccine development.
    • Data on pneumococcal serotype distribution in France during the late 1970s and early 1980s is essential.

    Purpose:

    • To determine the prevalent Streptococcus pneumoniae serotypes in French hospitals between 1977 and 1982.
    • To assess the potential vaccine coverage of existing and proposed pneumococcal vaccines.

    Summary:

    • A total of 2,449 pneumococcus strains were serotyped using the Danish system.
    • Serotypes 19, 6, and 23 were the most common overall, while serotypes 1, 19, and 6 predominated in invasive isolates (haemocultures and cerebrospinal fluids).
    • Vaccine efficacy analysis indicated 64.75% coverage for a 14-valent vaccine and 82.75% for a 23-valent vaccine against invasive strains.

    Impact:

    • Provides baseline data on pneumococcal serotype distribution in France, informing public health strategies.
    • Highlights the superior coverage of broader valency pneumococcal vaccines.
    • Contributes to the understanding of serotype epidemiology and its implications for vaccine impact assessments.

    More Related Videos

    Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination09:11

    Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

    Published on: September 24, 2014

    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/4306:06

    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

    Published on: September 11, 2020

    Related Concept Videos

    Pneumonia I: Introduction01:30

    Pneumonia I: Introduction

    Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
    Risk Factors
    Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
    Pneumonia III: Complications and Assessment01:30

    Pneumonia III: Complications and Assessment

    Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
    Atypical Pneumonia01:14

    Atypical Pneumonia

    Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
    Smallpox01:24

    Smallpox

    Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
    Bacterial Meningitis II: Pathophysiology01:26

    Bacterial Meningitis II: Pathophysiology

    Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...