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Tumour oxygenation under normobaric and hyperbaric conditions.
The British Journal of Radiology
|August 1, 1983
Summary
Hyperbaric oxygenation significantly improves tumour oxygenation, especially at 4 bar, reducing radiobiological hypoxia. This suggests hyperbaric oxygen is an effective adjuvant for X-ray cancer therapy, particularly for superficial tumours.
Area of Science:
- Oncology
- Radiation Oncology
- Biomedical Engineering
Background:
- Tumour oxygenation is critical for radiotherapy response.
- Radiobiological hypoxia can limit the effectiveness of X-ray irradiation.
- Hyperbaric oxygen therapy (HBOT) has been explored to enhance tumour oxygenation.
Purpose of the Study:
- To quantify tumour oxygenation under normobaric and hyperbaric oxygen conditions.
- To assess the impact of varying oxygen pressures on tumour oxygenation and radiobiological hypoxia.
- To evaluate HBOT as an adjuvant therapy for cancer treatment.
Main Methods:
- DS-carcinosarcomas in rats were exposed to oxygen at 1, 2, 3, and 4 bar.
- Tumour oxygenation was measured using a cryophotometric micromethod on cryobiopsies.
- Oxyhaemoglobin saturation (HbO2) of red blood cells in tumour microvessels was determined.
- Mean arterial blood pressure was monitored throughout pressurisation.
Main Results:
- Normobaric oxygen (1 bar) improved tumour oxygen supply compared to air.
- Pressurisation up to 3 bar significantly reduced the occurrence of low HbO2 values (<5%).
- Pressurisation to 4 bar shifted HbO2 distribution to higher values (>35%), indicating minimal radiobiological hypoxia.
- HBOT, particularly at 4 bar, enhances tumour oxygenation, potentially increasing radiosensitivity.
Conclusions:
- Hyperbaric oxygenation effectively improves tumour oxygenation in DS-carcinosarcomas.
- Pressurisation to 4 bar minimizes radiobiological hypoxia, making it a promising condition for HBOT.
- HBOT is a viable and efficient adjuvant to X-ray irradiation for superficial tumours.