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Related Experiment Videos

Intracranial pressure reserve testing. A study in experimental animals.

H A Wilkinson, D Arredondo, S Weems

    Archives of Neurology
    |September 1, 1978
    PubMed
    Summary

    Quantifying intracranial pressure (ICP) reserve, a measure of the brain's compensatory capacity, is valuable. Testing ICP reserve using multiple saline infusions over five minutes proved most reliable for clinical application.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Medical Monitoring

    Background:

    • Continuous intracranial pressure (ICP) monitoring is crucial for managing neurological conditions.
    • Quantifying cerebral elastance or ICP reserve enhances the value of ICP monitoring.
    • ICP reserve reflects the brain's ability to compensate for increased intracranial volume.

    Purpose of the Study:

    • To evaluate different methods for measuring intracranial pressure (ICP) reserve.
    • To determine the most reliable and clinically applicable method for ICP reserve testing.
    • To assess ICP reserve in canine models with induced intracranial masses.

    Main Methods:

    • Five distinct methods for measuring ICP reserve were employed.
    • Experiments involved dogs with known extracerebral intracranial masses.

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  • ICP reserve was tested under varying conditions, including normal and edematous brains at different ICP levels.
  • Multiple increments of subdural saline infusion over five minutes were used to assess ICP reactivity to volumetric stress.

    • Main Results:

    • Over ten thousand measurements were conducted across the five methods.
    • Testing ICP reserve using multiple, incremental subdural saline infusions over five minutes demonstrated the highest reliability.
    • Methods relying on a single subdural infusion for cerebral elastance measurement were found to be variable and difficult to interpret.

    Conclusions:

    • The method involving multiple five-minute subdural saline infusions is the most reliable and clinically adaptable for quantifying intracranial pressure (ICP) reserve.
    • Single-infusion methods for measuring cerebral elastance are less reliable and harder to apply clinically.
    • Accurate ICP reserve quantification aids in understanding and managing conditions affecting intracranial volume and pressure.