Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary protein patterns and preeclampsia.

F J Kaltenbach, W H Boesken, C Wilhelm

    Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ceftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2024
    Same author

    Studying the impact of geometrical and cellular cues on myogenesis with a skeletal muscle-on-chip.

    Lab on a chip·2024
    Same author

    Carbon dots, a powerful non-toxic support for bioimaging by fluorescence nanoscopy and eradication of bacteria by photothermia.

    Nanoscale advances·2022
    Same author

    Detection and differentiation of active and inactive isoforms of coagulation factors II, VII, IX, and X in prothrombin complex concentrate by mass spectrometry.

    Journal of pharmaceutical and biomedical analysis·2021
    Same author

    [Severe right-sided cephalalgia with right sixth nerve palsy].

    HNO·2020
    Same author

    Maghemite nanoparticles coated with human serum albumin: combining targeting by the iron-acquisition pathway and potential in photothermal therapies.

    Journal of materials chemistry. B·2020
    Same journal

    Propranolol in pregnancy three year prospective study.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    Same journal

    Renal histology and pregnancy performance in systemic lupus erythematosus.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    Same journal

    Urine dopamine during normotensive and hypertensive pregnancies and the puerperium.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    Same journal

    Pre-eclampsia in a second pregnancy.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    Same journal

    The relationship between posture and plasma catecholamines in the pregnant woman.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    Same journal

    The effect of essential fatty acid and specific vitamin supplements on vascular sensitivity in the mid-trimester of human pregnancy.

    Clinical and experimental hypertension. Part B, Hypertension in pregnancy·1983
    See all related articles

    Urinary protein patterns in preeclampsia can help differentiate kidney conditions. Early analysis of protein patterns is recommended for pregnant individuals with elevated blood pressure and proteinuria.

    Area of Science:

    • Nephrology
    • Obstetrics
    • Biochemistry

    Background:

    • Preeclampsia is a serious pregnancy complication characterized by high blood pressure and proteinuria.
    • Differentiating between preeclampsia-induced nephropathy and pre-existing kidney disease is crucial for appropriate management.
    • Urinary protein electrophoresis is a diagnostic tool that can analyze protein profiles in urine.

    Purpose of the Study:

    • To investigate if urinary protein patterns, analyzed by SDS-PAA-disc-electrophoresis, can distinguish between genuine preeclampsia-related nephropathies and those superimposed on pre-existing renal conditions.
    • To explore the relationship between proteinuria patterns, mean arterial pressure (MAP), and the underlying renal pathology in preeclamptic patients.

    Main Methods:

    • A retrospective study involving 107 pregnant patients in their third trimester diagnosed with preeclampsia.

    Related Experiment Videos

  • Analysis of urinary protein patterns using SDS-PAA-disc-electrophoresis.
  • Correlation of protein patterns with mean arterial pressure (MAP) and postpartum follow-up data for a subset of patients.

    • Main Results:

    • A mixed urinary protein pattern was observed in 47% of patients, irrespective of MAP severity, suggesting association with genuine preeclampsia.
    • The study could not definitively determine if pure glomerulopathies, which increased with MAP, were pre-existing.
    • Postpartum follow-up revealed pathological protein patterns or increased excretion in one-third of 22 patients, indicating 35% had pre-existing nephropathies, though differentiation was not always possible.

    Conclusions:

    • Urinary protein electrophoresis (SDS-PAA-analysis) shows potential in differentiating nephropathies in preeclampsia, but limitations exist.
    • A mixed protein pattern may indicate genuine preeclampsia-related kidney involvement.
    • Early SDS-PAA-analysis of urinary proteins is recommended for pregnant patients with rising MAP and proteinuria to aid in timely diagnosis and management.