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Related Experiment Videos

Plasma antithrombin III levels in pre-eclampsia.

G H Weenink, P E Treffers, P Vijn

    Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy
    |January 1, 1983
    PubMed
    Summary

    Antithrombin III (AT III) levels remained normal during pregnancy, except in women with hypertension. AT III depression in pre-eclampsia is linked to increased consumption and correlates with maternal complications.

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    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Clinical Chemistry

    Background:

    • Plasma antithrombin III (AT III) is a key protein in the coagulation cascade.
    • Understanding AT III levels during pregnancy is crucial for identifying potential complications.

    Purpose of the Study:

    • To investigate plasma AT III levels in a large cohort of pregnant women.
    • To determine the relationship between AT III levels and pregnancy-induced hypertension, specifically pre-eclampsia.
    • To assess the correlation of AT III with maternal morbidity and fetal outcomes.

    Main Methods:

    • Prospective study involving 2423 plasma samples from 653 women during pregnancy and postpartum.
    • Women were grouped based on diastolic blood pressure in the third trimester.

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  • AT III levels were measured and correlated with clinical outcomes.

    • Main Results:

    • Normal AT III levels were observed throughout pregnancy, labor, and postpartum, except in women with hypertension.
    • Evidence suggests AT III depression in pre-eclampsia results from increased consumption.
    • AT III levels correlated with hepatorenal damage and showed a weak correlation with placental infarction.
    • Proteinuria was the best predictor of fetal outcome, with AT III levels improving prediction accuracy.

    Conclusions:

    • Plasma AT III levels are generally stable during pregnancy but can be depressed in pre-eclampsia due to increased consumption.
    • AT III levels serve as a potential indicator of maternal morbidity in hypertensive disorders of pregnancy.
    • Postpartum AT III levels rapidly normalize after vaginal delivery.