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Related Experiment Videos

Propranolol in pregnancy three year prospective study.

I Livingstone, P W Craswell, E B Bevan

    Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy
    |January 1, 1983
    PubMed
    Summary

    Propranolol and methyldopa equally control pregnancy-associated hypertension. However, propranolol use in mothers resulted in one infant with symptomatic hypoglycemia, and its metabolites transfer to breast milk.

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    Area of Science:

    • Pharmacology
    • Obstetrics
    • Neonatology

    Background:

    • Pregnancy-associated hypertension is a common complication.
    • Beta-blockers like propranolol are used to manage hypertension during pregnancy.
    • Methyldopa is another commonly used antihypertensive agent in pregnancy.

    Purpose of the Study:

    • To compare the efficacy and safety of propranolol versus methyldopa in managing pregnancy-associated hypertension.
    • To assess maternal and neonatal outcomes in a randomized prospective study.

    Main Methods:

    • A randomized prospective study involving 28 women with pregnancy-associated hypertension.
    • Comparison of propranolol and methyldopa for hypertension control.
    • Evaluation of maternal hypertension, infant birthweights, and infant blood glucose levels.

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  • Analysis of propranolol and its metabolites in maternal plasma and breast milk across trimesters and postpartum.

    • Main Results:

    • Both propranolol and methyldopa were equally effective in controlling maternal hypertension.
    • No significant difference in infant birthweights between the two groups.
    • One infant born to a mother on propranolol experienced symptomatic hypoglycemia.
    • Propranolol and its metabolites cross into breast milk, with estimated infant intake being approximately 0.1% of the maternal dose.
    • Naphthoxylactic acid levels were significantly lower in the third trimester compared to postpartum.

    Conclusions:

    • Propranolol and methyldopa demonstrate comparable efficacy in treating pregnancy-associated hypertension.
    • While generally safe, propranolol use may be associated with a risk of symptomatic hypoglycemia in neonates.
    • The transfer of propranolol and its metabolites into breast milk is minimal, suggesting a low risk for breastfeeding infants.