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Lissencephaly: computed tomographic diagnosis.

J P Williams, J N Joslyn

    The Journal of Computed Tomography
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Lissencephaly is a rare congenital brain malformation. Computed tomography reveals characteristic features like absent sulci/gyri and white matter abnormalities.

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    Area of Science:

    • Neurology
    • Radiology
    • Developmental Biology

    Background:

    • Lissencephaly is a severe congenital brain malformation.
    • Characterized by smooth brain surface due to defective neuronal migration.
    • Understanding its imaging features is crucial for diagnosis.

    Observation:

    • Computed tomography (CT) is a key imaging modality.
    • CT demonstrates hallmark features of lissencephaly.
    • Specific findings aid in differentiating it from other conditions.

    Findings:

    • Key CT findings include agyria/lissencephaly (smooth cortex).
    • Other features: absent cortical sulci and gyri, calcification near the paraphysis.
    • Additional signs: wide, shallow sylvian fissures, colpocephaly, poor white matter development, persistent cavum septum pellucidum/cavum vergae.

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    Implications:

    • Accurate CT interpretation aids in early diagnosis of lissencephaly.
    • Facilitates genetic counseling and management planning.
    • Contributes to understanding the spectrum of cortical malformations.