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Related Experiment Videos

Hypoprothrombinemia in naproxen overdose.

P K Waugh, D W Keatinge

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1983
    PubMed
    Summary

    A 10-gram naproxen overdose caused temporary bleeding issues by affecting vitamin-K-dependent clotting factors. This suggests naproxen may directly inhibit the synthesis of essential proteins for blood coagulation.

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    The Western journal of medicineยท1992
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    Area of Science:

    • Pharmacology
    • Hematology
    • Toxicology

    Background:

    • Naproxen is a common nonsteroidal anti-inflammatory drug (NSAID).
    • Vitamin-K-dependent clotting factors are crucial for hemostasis.
    • Prothrombin time (PT) is a key indicator of the extrinsic pathway of coagulation.

    Observation:

    • A healthy individual experienced a transient prolongation of prothrombin time.
    • This occurred following a significant overdose of naproxen (10 grams).
    • The patient had no pre-existing conditions affecting coagulation, such as liver disease or bleeding disorders.

    Findings:

    • The overdose of naproxen was directly linked to the observed coagulopathy.
    • The most probable mechanism involves direct inhibition of vitamin-K-dependent clotting factor synthesis.
    • This may result from the production of an altered form of prothrombin.

    Implications:

    • Naproxen overdose can lead to acquired coagulation defects.
    • This highlights a potential mechanism of NSAID-induced bleeding.
    • Further research may elucidate the specific molecular interactions between naproxen and clotting factor synthesis.

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