Bromocriptine inhibits 2-deoxy-D-glucose-stimulated gastric acid secretion in the rat

The influence of bromocriptine on the secretagogue-induced gastric acid secretion was examined in rats. The drug inhibited the gastric acid secretion centrally stimulated by 2-deoxy-D-glucose (2DG) in anesthetized or conscious rats. Apomorphine also prevented 2DG-induced acid secretion in anesthetized rats but not in conscious rats. Neither bromocriptine nor apomorphine significantly influenced the acid secretion induced peripherally by electrical vagus stimulation or gastrin. The antisecretory effect of bromocriptine was reversed by dopamine antagonists in anesthetized or conscious rats, but not by apomorphine in anesthetized rats. The results suggest that in rats, the antisecretory effect of bromocriptine on 2DG-stimulated acid secretion is partly due to its central dopamine agonistic action, but that of apomorphine may be due to dopaminergic plus other mechanisms.