[Changes in the systemic and regional circulation responses to immobilization stress in the rat after pharmacological...

A preliminary pharmacological desympathization (pirroxan, obzidan, ornid) decreased blood pressure, heart rate, cardiac output, and increased total vascular resistance in immobilized rats. The fraction of cardiac output decreased in lung (bronchial blood flow), liver and myocardium and increased in other organs and tissues. Relative blood supply increased in expansive regions of the skin, muscles and splanchnic organs but decreased in the liver. Opposite changes of transcapillary permeability were found in vascular regions of the skin and skeletal muscles as well as in splanchnic organs.