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[Intravenous loading with galactose as a liver function test. Methods and clinical value].

H D Kuntz, E Kuntz

    Fortschritte Der Medizin
    |June 2, 1983
    PubMed
    Summary
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    The galactose elimination capacity test quantifies liver metabolic function by measuring functional hepatocyte mass. This reliable, safe intravenous galactose test aids in assessing liver disease severity for routine hepatological investigations.

    Area of Science:

    • Hepatology and Clinical Biochemistry
    • Diagnostic Medicine

    Context:

    • Assessing liver function is crucial for diagnosing and managing liver diseases.
    • Existing methods may be confounded by factors like bilirubin levels or hyperlipidemia.
    • A need exists for a reliable, quantitative measure of functional liver mass.

    Purpose:

    • To evaluate the galactose elimination capacity (GEC) test as a quantitative measure of liver metabolic function.
    • To assess the reliability and safety of the intravenous galactose test, based on Tygstrup's method (1966).

    Summary:

    • The intravenous galactose elimination capacity test accurately reflects functional hepatocyte mass, offering a quantitative assessment of liver metabolic function.
    • This method is unaffected by bilirubin, hemolysis, or hyperlipidemia, providing reliable results even in hepatic secretion disorders.

    Related Experiment Videos

  • Galactose can be measured in capillary blood, and the test is associated with minimal side effects.

    • Impact:

    • The galactose elimination capacity test provides a valuable tool for estimating liver disease severity.
    • It is suitable for routine use in hepatological assessments and specific clinical investigations.
    • This quantitative method enhances the diagnostic capabilities in liver disease management.