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Related Experiment Videos

The lung parenchyma in burns.

P S Hasleton, L McWilliam, N Y Haboubi

    Histopathology
    |May 1, 1983
    PubMed
    Summary

    Pulmonary changes in burn victims, including edema and hemorrhage, occur within 48 hours. These findings challenge the concept of oxygen toxicity in humans, even with prolonged oxygen therapy.

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    Area of Science:

    • Pathology
    • Pulmonary Medicine
    • Burn Injury Research

    Background:

    • Burns can lead to significant pulmonary complications.
    • The role of inspired oxygen in burn-related lung injury is debated.
    • Understanding lung pathology post-burn is crucial for patient outcomes.

    Purpose of the Study:

    • To correlate clinicopathological findings in the lungs of burn victims.
    • To investigate the temporal evolution of pulmonary changes after burns.
    • To assess the relationship between oxygen therapy and lung pathology.

    Main Methods:

    • Clinicopathological analysis of 68 lung autopsy cases from burn victims.
    • Sequential analysis of pulmonary changes within the first 48 hours and beyond.
    • Correlation of findings with the level and duration of oxygen therapy.

    Main Results:

    • Early pulmonary changes (0-48h) included congestion, edema, hemorrhage, and 'giant endothelial cells'.
    • Later changes (after 48h) involved microthrombi (disseminated intravascular coagulation), pneumonia, and septicaemia.
    • Hyaline membranes and fibrosis were uncommon; no correlation found with oxygen therapy parameters.

    Conclusions:

    • Pulmonary pathology in burn victims evolves over time, with distinct early and late changes.
    • Disseminated intravascular coagulation, pneumonia, and septicaemia are common complications.
    • The study questions the clinical relevance of oxygen toxicity in human burn patients.

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