Manganese-52m for direct application: a new 52Fe/52mMn generator based on a hydroxamate resin

A new generator system has been developed using the 52Fe/52mMn parent-daughter pair. A polymeric hydroxamate resin is used for the fixation of 52Fe, and the short-lived positron-emitter 52mMn is eluted in physiological saline. Preliminary animal studies in rats gave similar results with respect to biodistribution as are obtained for [54Mn] manganous chloride.