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Autonomic dysfunction in palmar hyperhidrosis.

C J Shih, J J Wu, M T Lin

    Journal of the Autonomic Nervous System
    |May 1, 1983
    PubMed
    Summary
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    Sympathetic fibers through T2-3 ganglia modulate autonomic functions. Hyperhidrotic subjects show dysfunction due to overactive sympathetic fibers, which can be corrected by interrupting these pathways.

    Area of Science:

    • Neuroscience
    • Autonomic Nervous System Research
    • Surgical Neurology

    Background:

    • Palmar hyperhidrosis is linked to sympathetic nervous system activity.
    • The T2-3 ganglia are critical for sympathetic nerve pathways controlling various bodily functions.
    • Autonomic dysfunction can manifest in individuals with hyperhidrosis.

    Purpose of the Study:

    • To investigate the role of sympathetic fibers passing through the T2-3 ganglia in autonomic function.
    • To compare autonomic responses in normal, hyperhidrotic, and denervated individuals.
    • To determine if interrupting T2-3 sympathetic pathways can resolve autonomic dysfunction in hyperhidrosis.

    Main Methods:

    • Assessed sudomotor, baroreceptor, and vasomotor functions in three groups: normal, hyperhidrotic, and denervated (post-T2-3 ganglionectomy).

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  • Evaluated sweating responses to body exercise and cardiovascular responses to Valsalva maneuver, face immersion, and cold immersion.
  • Compared physiological data across the three subject groups.

    • Main Results:

    • Denervated subjects showed altered sweating patterns (less on upper body, more on lower body) compared to normal and hyperhidrotic groups.
    • Hyperhidrotic subjects exhibited reduced reflex bradycardia and increased cutaneous vasoconstriction compared to normal and denervated groups.
    • Data suggest T2-3 sympathetic fibers are crucial for autonomic function modulation, with hyperhidrosis linked to overactivity.

    Conclusions:

    • Sympathetic fibers traversing the T2-3 ganglia significantly influence autonomic functions.
    • Hyperhidrotic individuals may experience autonomic dysfunction due to overactive sympathetic fibers at the T2-3 level.
    • Interruption of excessive sympathetic activity via T2-3 ganglionectomy can normalize autonomic dysfunctions in hyperhidrosis.