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Schizophrenia, abnormal connection, and brain evolution.

P L Randall

    Medical Hypotheses
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Brain connectivity abnormalities may cause schizophrenia symptoms, impacting callosal and intrahemispheric fibers. These issues, linked to brain evolution, can also influence other neurodevelopmental disorders.

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    Area of Science:

    • Neuroscience
    • Neurobiology
    • Evolutionary Psychology

    Background:

    • Schizophrenia syndrome is associated with abnormal functional connections between specialized brain regions.
    • Both callosal and intrahemispheric fibers are implicated in these functional abnormalities.
    • The timing of symptom emergence may relate to the myelination of specific fiber groups.

    Purpose of the Study:

    • To explore the link between brain connectivity, evolution, and neurodevelopmental disorders.
    • To hypothesize the role of myelination in the manifestation of schizophrenia and related syndromes.
    • To understand how brain evolution might lead to both enhanced abilities and abnormalities.

    Main Methods:

    • Conceptual analysis of brain maturation, myelination, and functional connectivity.

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  • Theoretical modeling of evolutionary processes in neural development.
  • Review of existing literature on schizophrenia, dyslexia, and other neurodevelopmental conditions.

    • Main Results:

    • Abnormal functional connections are proposed as a key mechanism underlying schizophrenia.
    • Similar mechanisms may underlie dyslexia and other neurodevelopmental disorders like Kanner syndrome and Gilles de la Tourette syndrome.
    • Brain evolution, through trial and error in neural connections, can result in a spectrum of abilities and abnormalities.

    Conclusions:

    • Abnormal functional brain connectivity is a potential consequence of vertebrate brain evolution.
    • Both normal and abnormal connectivity patterns are integral to the evolutionary process.
    • A dormant potential for schizophrenia may exist, triggered by precipitating factors.