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Effect of dopamine on phosphate reabsorption in isolated perfused rabbit proximal tubules
Mineral and Electrolyte Metabolism
|January 1, 1983
Abstract:
The effect of dopamine (10(-6) M) on PO4 reabsorption was studied in isolated and perfused proximal convoluted and straight tubules of the rabbit. In convoluted tubules, fluid reabsorption (JV), PO4 lumen-to-bath (JPO4lb), and net (net JPO4) fluxes did not change during dopamine exposure. In S3 segments bathed in rabbit serum, JV diminished significantly during dopamine exposure. JPO4 decreased by 20% (p less than 0.005) and net JPO4 decreased by 27% (p less than 0.02). The effect of dopamine was reversible upon removal of the drug.