Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A functional role for vasoactive intestinal polypeptide in anterior cingulate cortex.

J McCulloch, P A Kelly

    Nature
    |August 4, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient experiences of left-sided colorectal resection by robotic, conventional laparoscopic and open approaches: a qualitative study.

    Techniques in coloproctology·2023
    Same author

    Control of carbapenemase-producing Enterobacteriaceae outbreaks in acute settings: an evidence review.

    The Journal of hospital infection·2016
    Same author

    ePathGen--a new e-learning package in pathogen genomics.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2014
    Same author

    Phosphorus retention in a mesotrophic lake under transient loading conditions: insights from a sediment phosphorus binding form study.

    Water research·2013
    Same author

    Local cerebral glucose utilization after chronic electroconvulsive shock: implications for the mode of action of electroconvulsive therapy.

    Journal of psychopharmacology (Oxford, England)·2012
    Same author

    Proteomic data in meningiomas: post-proteomic analysis can reveal novel pathophysiological pathways.

    Journal of neuro-oncology·2011
    Same journal

    Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

    Nature·2026
    Same journal

    China boosts prestigious grants for young scientists - will it ease competition?

    Nature·2026
    Same journal

    Incoming US science academy chief vows to 'double down' on research.

    Nature·2026
    Same journal

    Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

    Nature·2026
    Same journal

    Electrodeposited self-assembled molecules for perovskite photovoltaics.

    Nature·2026
    Same journal

    Neutrino's nursery found: the 'Shadow Blaster'.

    Nature·2026
    See all related articles

    Vasoactive intestinal polypeptide (VIP) influences brain activity. This study shows VIP injection increases glucose metabolism in the rat anterior cingulate cortex and connected brain regions, suggesting a role in information processing.

    Area of Science:

    • Neuroscience
    • Peptide Signaling
    • Cerebral Cortex Function

    Background:

    • Vasoactive intestinal polypeptide (VIP) is abundant in the cerebral cortex and acts as a neurotransmitter.
    • VIP has specific binding sites and activates adenylate cyclase in cortical tissue.
    • The functional role of VIP in the central nervous system (CNS) remains challenging to define.

    Purpose of the Study:

    • To investigate the functional role of VIP in the anterior cingulate cortex.
    • To map changes in brain activity following VIP administration using glucose utilization.
    • To identify CNS regions affected by VIP in the anterior cingulate cortex.

    Main Methods:

    • Quantitative autoradiographic 14C-deoxyglucose technique in rats.
    • Unilateral injection of VIP (20 pmol) into the anterior cingulate cortex.

    Related Experiment Videos

  • Analysis of local and remote changes in glucose utilization.

    • Main Results:

    • VIP injection increased glucose utilization in the anterior cingulate cortex.
    • Focal alterations in glucose use were observed in connected CNS regions, including the mediodorsal thalamus, ventral tegmental area, nucleus accumbens, caudate nucleus, and contralateral cingulate cortex.
    • These changes indicate a widespread effect of VIP on brain metabolism.

    Conclusions:

    • VIP administration leads to increased glucose metabolism in the anterior cingulate cortex and associated brain areas.
    • These findings suggest VIP plays a role in modulating information processing within the anterior cingulate cortex.
    • VIP influences neuronal activity in brain regions connected to the anterior cingulate cortex.