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Related Experiment Videos

Age-related changes in rat brain capillaries.

P Hicks, C Rolsten, D Brizzee

    Neurobiology of Aging
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Aging alters brain capillaries differently in the frontal cortex and hippocampus. Capillary basement membranes thicken, and mitochondria increase in specific brain regions, suggesting regional variations in aging effects on brain vasculature.

    Area of Science:

    • Neuroscience
    • Aging Research
    • Cerebrovascular Biology

    Background:

    • Capillary morphology changes with age.
    • Brain aging impacts cognitive function.
    • Understanding age-related vascular changes is crucial.

    Purpose of the Study:

    • To investigate age-associated morphological changes in rat brain capillaries.
    • To compare changes in the frontal cortex (FC) and hippocampal CA1 (HC) regions.
    • To identify regional variations in capillary aging.

    Main Methods:

    • Electron microscopy was used to examine capillary structures.
    • Morphological parameters were measured in male Fischer 344 rats at 3, 9, and 24 months of age.
    • Quantitative analysis of basement membrane, endothelial cells, pericytes, and mitochondria.

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    Main Results:

    • Increased basement membrane cross-sectional area with age.
    • Increased mitochondrial volume fraction in FC endothelial and pericyte cytoplasm.
    • Increased pericyte mitochondrial size in both FC and HC.
    • Increased capillary lumen area in FC, decreased in HC.
    • Pericyte mitochondria were larger than endothelial cell mitochondria.

    Conclusions:

    • Capillary morphometrics exhibit regional variations in age-related changes.
    • Aging affects brain vasculature differently between the frontal cortex and hippocampus.
    • These findings contribute to understanding the neurobiology of aging.