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Lecithin bilayers. Density measurement and molecular interactions.

J F Nagle, D A Wilkinson

    Biophysical Journal
    |August 1, 1978
    PubMed
    Summary
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    Density measurements reveal that hydrocarbon chain interactions and rotational isomeric energies drive lecithin bilayer main phase transitions. These transitions are analogous to alkane melting, with volume changes primarily due to hydrocarbon chains.

    Area of Science:

    • Biophysics
    • Materials Science
    • Physical Chemistry

    Background:

    • Lecithin bilayers exhibit complex phase transitions influenced by lipid chain length.
    • Understanding these transitions is crucial for biomembrane and materials science applications.

    Purpose of the Study:

    • To quantify volume changes during phase transitions in saturated lecithin bilayers.
    • To elucidate the molecular origins of these transitions using density and X-ray data.
    • To compare lecithin transitions with melting transitions in alkanes and polyethylene.

    Main Methods:

    • Density measurements of lecithin bilayer dispersions.
    • X-ray diffraction analysis.
    • Thermodynamic calculations of volume and energy changes.

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    Main Results:

    • Volume changes at the main transition increase with lecithin chain length (14-18 carbons).
    • Hydrocarbon chains dominate volume changes, allowing calculation of methylene group volume.
    • Interchain van der Waals energy changes correlate with transition enthalpies across lecithins, alkanes, and polyethylene.

    Conclusions:

    • Lecithin bilayer main phase transitions are driven by hydrocarbon chain interactions and rotational isomeric energies.
    • The main transition is analogous to alkane melting, with modifications.
    • Calculations consistently balance energy equations for lecithins, alkanes, and polyethylene.