Studies on RES function in rats and mice after different doses of fluosol

Changes in the activity of the RES were examined by: 1. the clearance of colloidal carbon in rats (expressed by the elimination constant K); 2. determination of the tolerance of endotoxin in mice and that of gram negative enterobacteria in rats (expressed in both methods by the lethality); 3. evaluation of the temporal course of weight and the amount of PFCs taken up by two chief organs of the RES--liver and spleen. The results revealed a distinct temporal action of PFCs on the function of the RES which was terminated before cellular responses ended.