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Clinical experience with Fluosol-DA.

S A Gould, A L Rosen, L R Sehgal

    Progress in Clinical and Biological Research
    |January 1, 1983
    PubMed
    Summary
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    Perfluorochemicals like Fluosol-DA are promising acellular oxygen carriers. Fluosol-DA proved necessary and effective for maintaining adequate oxygen levels at a safe fraction of inspired oxygen (FiO2) of 0.6.

    Area of Science:

    • Biomedical Engineering
    • Hematology

    Background:

    • Perfluorochemicals (PFCs) are artificial oxygen carriers.
    • Acellular oxygen carriers offer potential advantages over traditional blood transfusions.
    • Fluosol-DA is a specific PFC emulsion investigated for oxygen transport.

    Purpose of the Study:

    • To evaluate the necessity and efficacy of Fluosol-DA as an acellular oxygen carrier in a clinical setting.
    • To determine the oxygen-carrying capacity of plasma alone versus plasma supplemented with Fluosol-DA at varying fractions of inspired oxygen (FiO2).

    Main Methods:

    • Case study of a single patient.
    • Monitoring of oxygen content in plasma and Fluosol-DA at FiO2 1.0 and 0.6.
    • Assessment of oxygen adequacy based on physiological requirements.

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    Main Results:

    • At FiO2 1.0, plasma oxygen content was adequate, but FiO2 was unsafe.
    • At a safe FiO2 of 0.6, plasma oxygen alone was inadequate.
    • Fluosol-DA was required and effective at FiO2 0.6, ensuring adequate total oxygen content.
    • The benefit of Fluosol-DA was temporary.

    Conclusions:

    • Fluosol-DA is a necessary and effective acellular oxygen carrier at a safe FiO2 of 0.6.
    • Further clinical and multicenter studies are needed to address the temporary nature of its benefit and long-term efficacy.