Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental retinal tolerance to liquid silicone.

R R Ober, J C Blanks, T E Ogden

    Retina (Philadelphia, Pa.)
    |January 1, 1983
    PubMed
    Summary

    Intraocular liquid silicone injections did not harm rabbit retinas. Electroretinogram (ERG) tests and microscopy showed no significant toxic effects from silicone over six months.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paediatric toe-to-hand transfer: an assessment of outcomes from a single unit.

    The Journal of hand surgery, European volume·2015
    Same author

    The antidiuretic action of morphine: its site and mode of action in the hypothalamus of the dog.

    Quarterly journal of experimental physiology and cognate medical sciences·2014
    Same author

    Control of the secretion of antidiuretic hormone from the pars nervosa of the pituitary gland.

    Physiological reviews·2010
    Same author

    Local-anaesthetic day-case treatment of Stelling type 1 ulnar duplication in babies up to 4 months of age.

    The Journal of hand surgery, European volume·2010
    Same author

    Calcification of a molteno implant.

    Journal of glaucoma·2009
    Same author

    Effect of 5-Fluorouracil on corneoscleral wound healing.

    Journal of glaucoma·2009

    Area of Science:

    • Ophthalmology
    • Retinal Science
    • Biomaterials

    Background:

    • Intraocular liquid silicone is used in retinal detachment surgery.
    • Understanding its long-term effects on retinal function and structure is crucial.

    Purpose of the Study:

    • To evaluate the toxic effects of intraocular liquid silicone on the electroretinogram (ERG) and retinal morphology in rabbits.
    • To assess the safety of 1000 centistokes liquid silicone over a 6-month period.

    Main Methods:

    • Rabbits underwent vitrectomy followed by injection of liquid silicone or balanced salt solution (BSS).
    • Electroretinograms (ERG) were recorded.
    • Retinal morphology was examined using light and electron microscopy.
    • Clinical follow-up ranged from 3 days to 6 months.

    Related Experiment Videos

    Main Results:

    • Liquid silicone was clinically well-tolerated in rabbit eyes.
    • ERG responses were comparable between silicone-injected and control eyes.
    • Microscopy revealed minor, similar changes in both groups, attributed to surgical trauma or fixation artifacts.

    Conclusions:

    • Intraocular liquid silicone (1000 centistokes) demonstrates no toxic effect on the rabbit retina up to 6 months post-injection.
    • The findings support the safety of using liquid silicone in ophthalmic procedures.