Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heparin-like activity in uterine fluid.

M E Foley, B D Griffin, M Zuzel

    British Medical Journal
    |July 29, 1978
    PubMed
    Summary

    Heparin-like activity was found in uterine fluid, particularly in women with menorrhagia. This activity shows cyclical variations throughout the menstrual cycle.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dental Association of Canada West.

    The Dental register·2021
    Same author

    Dental Association of Ontario.

    The Dental register·2021
    Same author

    The Haemostatic Mechanism and Menstruation: The Role of Intra-Uterine Contraceptive Devices.

    Thrombosis and haemostasis·2019
    Same author

    Yorkshire Case Control Study of Leukaemias and Lymphomas Parallel Multivariate Analyses of Seven Disease Categories.

    Leukemia & lymphoma·2016
    Same author

    Selected applications of balloon dissection.

    Surgical technology international·2011
    Same author

    The Obligations of Humanity to the Medical Profession.

    Journal of the National Medical Association·2010

    Area of Science:

    • Gynecology
    • Hematology
    • Reproductive Biology

    Background:

    • Uterine fluid composition can influence reproductive health.
    • Heparin-like substances may play a role in local hemostasis and menstrual physiology.

    Purpose of the Study:

    • To investigate the presence and characteristics of heparin-like activity in human uterine fluid.
    • To explore potential correlations between this activity, menorrhagia, and the menstrual cycle.

    Main Methods:

    • Uterine fluid samples were collected from normal and menorrhagic patients.
    • Heparin-like activity was quantified using an anti-Xa heparin assay.
    • Fibrinogen-fibrin degradation products (FDPs) and mast cell counts were assessed.

    Main Results:

    Related Experiment Videos

    • Heparin-like activity was detected in most uterine fluid samples.
    • Activity was higher, though not significantly, in patients with menorrhagia.
    • Activity exhibited cyclical variation, increasing through the cycle and decreasing during menstruation.

    Conclusions:

    • Uterine fluid contains heparin-like activity with potential cyclical variations.
    • This activity may be relevant to menstrual disorders like menorrhagia.
    • Further research is needed to elucidate the precise role and source of this activity.