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Related Experiment Videos

Herd immunity and measles.

J P Fox

    Reviews of Infectious Diseases
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Herd immunity requires specific conditions not met in real-world populations. Even high immunity levels may not prevent disease outbreaks in clustered, susceptible subgroups.

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    Area of Science:

    • Epidemiology
    • Immunology
    • Public Health

    Background:

    • Herd immunity is a key concept in infectious disease control.
    • Traditional models assume random population mixing, which is often unrealistic.

    Purpose of the Study:

    • To evaluate the applicability of herd immunity concept in real-world populations.
    • To identify factors influencing disease transmission despite high immunity levels.

    Main Methods:

    • Analysis of disease transmission patterns in non-randomly mixing populations.
    • Case study using measles outbreaks in diverse settings.

    Main Results:

    • Herd immunity is only applicable under strict conditions: single host species, direct contact transmission, and solid immunity.

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  • Non-homogeneous distribution of susceptibles (clustering by age, socioeconomic status) facilitates epidemics.
  • Measles outbreaks persist in under-immunized subgroups despite high overall population immunity.

    • Conclusions:

    • Achieving herd immunity requires understanding susceptible distribution, not just overall prevalence.
    • Targeted strategies to reduce susceptible clusters are crucial for effective immunization programs.