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Automated platelet production during plasmapheresis.

G Rock, R Herzig, N McCombie

|July 1, 1983

Summary

Automated plasmapheresis machines can now collect plasma and platelet concentrate simultaneously. This modification enhances efficiency and cost-effectiveness for blood donation centers, benefiting both donors and recipients.

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Area of Science:

Blood component collection
Transfusion medicine
Biomedical engineering

Background:

Manual plasmapheresis is time-consuming and carries risks.
Existing automated plasmapheresis collects plasma but not sufficient platelets.
Current methods require significant donor time and resources.

Purpose of the Study:

To modify an automated plasmapheresis system for simultaneous plasma and platelet concentrate collection.
To assess the yield and quality of collected platelet concentrates.
To evaluate the efficiency and cost-effectiveness of the modified procedure.

Main Methods:

Automated plasmapheresis system modified by reducing g-force from 1200g to 650g.
Simultaneous collection of 500 ml plasma and 3 units of platelet concentrate.
Analysis of platelet yield, size distribution, in-vitro function, 51Cr survival, and post-transfusion increment.

Main Results:

Successful simultaneous collection of plasma and platelet concentrate in under 50 minutes.
Average platelet yield of 2.21 x 10(11) platelets per collection.
Collected platelets demonstrated normal size distribution, in-vitro function, 51Cr survival, and post-transfusion increment.

Conclusions:

The modified automated plasmapheresis system offers increased flexibility and efficiency.
This innovation allows for cost-effective generation of both plasma and platelet concentrate from random volunteer donors.
The procedure enhances the utility of automated cell separators in blood donation settings.

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