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Related Experiment Videos

R-R variations, a test of autonomic dysfunction.

A Persson, G Solders

    Acta Neurologica Scandinavica
    |May 1, 1983
    PubMed
    Summary

    Beat-to-beat heart rate variation effectively assesses autonomic function. Age impacts these variations, and conditions like diabetic polyneuropathy show significant differences in healthy individuals.

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    Area of Science:

    • Autonomic Nervous System Function
    • Cardiovascular Physiology
    • Neurology

    Background:

    • Autonomic dysfunction is a common complication of diabetes.
    • Assessing autonomic function is crucial for diagnosing and managing various neurological and cardiovascular conditions.
    • Heart rate variability (HRV) is a non-invasive method to evaluate autonomic nervous system (ANS) activity.

    Purpose of the Study:

    • To investigate beat-to-beat heart rate variation as a measure of autonomic function.
    • To establish normal criteria for heart rate variation, considering factors like age and wakefulness.
    • To compare heart rate variation in healthy volunteers with patients suffering from diabetic polyneuropathy and autonomic failure.

    Main Methods:

    • Recordings of beat-to-beat heart rate variation were obtained during quiet breathing, deep breathing, and postural changes (tilting from supine to upright).
    • Heart rate variations were quantified as a percentage of the mean R-R interval.
    • The influence of age, wakefulness, and intra-individual variability was assessed in healthy volunteers to define normal parameters.

    Main Results:

    • A significant negative correlation was observed between age and all measured heart rate variation parameters.
    • Patients with diabetic polyneuropathy exhibited distinct heart rate variation patterns compared to age-matched healthy controls.
    • Individuals with symptoms of autonomic failure demonstrated reduced heart rate variations relative to those without such symptoms.

    Conclusions:

    • Beat-to-beat heart rate variation is a valuable, sensitive indicator of autonomic nervous system function.
    • Age is a significant factor influencing normal heart rate variation, necessitating age-adjusted reference values.
    • Reduced heart rate variation is indicative of autonomic dysfunction, particularly in patients with diabetic polyneuropathy and autonomic failure.

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