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Related Experiment Videos

Increased cortisol excretion in chronic pain.

R A Moore, P J Evans, R F Smith

    Anaesthesia
    |August 1, 1983
    PubMed
    Summary

    Elevated urine cortisol creatinine ratio was found in 31% of chronic pain patients. This finding was not linked to pain severity, mood, or treatment, suggesting a potential biomarker for certain chronic pain conditions.

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    Area of Science:

    • Endocrinology
    • Pain Medicine
    • Clinical Chemistry

    Background:

    • Chronic pain affects a significant portion of the population.
    • Cortisol, a stress hormone, plays a role in pain perception and modulation.
    • The urine cortisol/creatinine ratio is a non-invasive biomarker for assessing cortisol levels.

    Purpose of the Study:

    • To investigate the prevalence of elevated urine cortisol/creatinine ratio in patients with chronic pain.
    • To explore potential correlations between elevated ratios and clinical characteristics of chronic pain.

    Main Methods:

    • Urine samples were collected from 67 chronic pain patients.
    • Patients on steroids or with Cushing's syndrome symptoms were excluded.
    • Urine cortisol and creatinine levels were measured to determine the ratio.

    Main Results:

    • 31% of patients exhibited elevated urine cortisol/creatinine ratios.
    • Some patients showed grossly elevated ratios.
    • No significant differences were found based on pain scores, mood, pain etiology, or drug therapy.
    • Elevated ratios were more common in patients with shorter pain duration.

    Conclusions:

    • An elevated urine cortisol/creatinine ratio is prevalent in a subset of chronic pain patients.
    • The ratio may serve as a potential, yet uncharacterized, biomarker in chronic pain.
    • Further research is needed to understand the clinical implications and interpretations of these findings.

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