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Related Experiment Videos

Relation between the urinary cortisol:creatinine ratio and hypoglycaemia.

A E Ohwovoriole, I M Nairn, J D Baird

    Annals of Clinical Biochemistry
    |May 1, 1983
    PubMed
    Summary
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    Urinary cortisol/creatinine ratio (UCCR) increases after hypoglycemia, especially in those with good adrenal response. Measuring UCCR may help detect nocturnal hypoglycemia in diabetic patients.

    Area of Science:

    • Endocrinology
    • Metabolic disorders

    Background:

    • Hypoglycemia can impact cortisol levels.
    • Assessing the body's stress response is crucial in diabetes management.

    Purpose of the Study:

    • To investigate the relationship between urinary free cortisol, urinary creatinine, and glycemic levels.
    • To determine if the urinary cortisol/creatinine ratio (UCCR) can indicate hypoglycemia, particularly nocturnal hypoglycemia.

    Main Methods:

    • Studied urinary free cortisol and creatinine concentrations in normal, insulin-stressed, and insulin-treated diabetic subjects.
    • Measured the urinary cortisol/creatinine ratio (UCCR) before and after an insulin tolerance test (ITT).
    • Correlated UCCR with capillary blood glucose levels at 03:00 in insulin-treated diabetics.

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    Main Results:

    • A positive linear correlation between urinary free cortisol and creatinine was observed in non-hypoglycemic subjects, but this was lost during hypoglycemia.
    • The highest mean UCCR was found post-ITT, significantly higher than pre-ITT levels.
    • A negative correlation existed between 03:00 blood glucose and overnight UCCR in insulin-treated diabetics.

    Conclusions:

    • Hypoglycemia leads to increased UCCR in individuals with adequate adrenocortical response.
    • UCCR measurement may serve as a useful tool for detecting nocturnal hypoglycemia.