Pharmacokinetic parameters for thallium (I)-ions in man

The pharmacokinetics of Tl+ were studied in 9 patients who underwent myocardial scintigraphy with 201Tl+. The time course of the 201Tl+ concentration fitted to an open two-compartment model. The following values were calculated: k12 = 0.164 +/- 0.025 min-1, k21 = 0.011 +/- 0.004 min-1, k10 = 0.005 +/- 0.004 min-1, t1/2(lambda 1) = 3.92 +/- 0.54 min, t 1/2(lambda 2) = 3108 +/- 896 min, CL = 0.08 +/- 0.03 l/min, V1 = 0.26 +/- 0.13 l/kg, Vz = 4.36 +/- 0.65 l/kg, Vss = 4.23 +/- 0.67 l/kg. Using previously published dialysance values the influence of hemodialysis on Tl+ elimination was calculated. Hemodialysis in Tl+ intoxications should be moderately effective.