Calculation of pharmacokinetic parameters from hemodialysis or hemoperfusion data--a mathematical treatise

A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the appropriate model in a particular intoxication. No prior knowledge of the time of application or of the dose of the toxic substance is needed. The pharmacokinetic parameters may be helpful to estimate the benefit of hemodialysis or hemoperfusion, respectively, in future intoxications.