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Apolipoprotein E polymorphism and coronary artery disease.

H J Menzel, R G Kladetzky, G Assmann

    Arteriosclerosis (Dallas, Tex.)
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Apolipoprotein E3/2 heterozygosity may protect against atherosclerosis, while E2/2 homozygosity doesn't increase coronary risk. This study analyzed lipid status and apolipoprotein E phenotypes in patients and controls.

    Area of Science:

    • Cardiovascular Medicine
    • Genetics
    • Biochemistry

    Background:

    • Apolipoprotein E (ApoE) phenotypes influence lipid metabolism and cardiovascular disease risk.
    • Understanding the association between ApoE phenotypes and coronary atherosclerosis is crucial for risk stratification.

    Purpose of the Study:

    • To investigate the relationship between lipid profiles, apolipoprotein E phenotypes, and coronary atherosclerosis in a patient cohort.
    • To determine the specific roles of different ApoE genotypes in the development of coronary artery disease.

    Main Methods:

    • Lipid status and apolipoprotein E phenotypes were analyzed in 1000 patients undergoing coronary angiography and 1000 healthy factory employees.
    • Frequencies of six distinct apolipoprotein E phenotypes (E3/3, E4/4, E2/2, E4/3, E3/2, E4/2) were determined in both groups.

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  • Biochemical markers including cholesterol, triglycerides, and high-density lipoprotein cholesterol were measured.

    • Main Results:

    • Apolipoprotein E3/2 heterozygotes were found more frequently in patients without coronary sclerosis, suggesting a protective effect.
    • Cholesterol and triglyceride levels were significantly elevated in patients with coronary artery disease.
    • Apolipoprotein E2/2 homozygosity was not associated with an increased risk of coronary atherosclerosis, despite elevated beta-very low-density lipoproteins.

    Conclusions:

    • Apolipoprotein E3/2 heterozygosity may confer a protective effect against early atherosclerosis.
    • Apolipoprotein E2/2 homozygosity is not a reliable biochemical indicator for increased coronary atherosclerosis risk.
    • Lipid profiles, particularly elevated cholesterol and triglycerides, are significant indicators of coronary artery disease.